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Targeting Cues from the Extracellular Matrix to Re-educate Tumor Immunity
Tissues are made up of cells surrounded by a complex and site specific 3D network of extracellular matrix. Emerging multi-omic technologies provide high resolution information that allows us to deconstruct the cellular and matrix components of all human tissues, to map their organization into spatially distinct local neighbourhoods, and to reconstruct the bidirectional conversations between cells and their microenvironment that dictate homeostatic tissue structure and function.
Understanding how this dialogue changes in disease, and in particular within the tumor microenvironment, reveals a rich source of novel, tractable, therapeutic targets with which to alter the immune axis, preventing tumor subversion of host defence and re-instating tumor-destructive inflammatory programmes.
Date:
18 July 2023, 9:30
Venue:
Wellcome Building, Headington OX3 7JX
Venue Details:
Room A+B
Speaker:
Professor Kim Midwood (Kennedy Institute of Rheumatology)
Organisers:
Prof Tao Dong (CAMS Oxford Institute, University of Oxford),
Dr Ricardo Fernandes (CAMS Oxford Institute, University of Oxford)
Hosts:
Prof Tao Dong (CAMS Oxford Institute, University of Oxford),
Dr Ricardo Fernandes (CAMS Oxford Institute, University of Oxford)
Part of:
CAMS Oxford Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Xiaowei Jie
