OxTalks is Changing
During Michaelmas Term, OxTalks will be moving to a new platform (full details are available on the Staff Gateway).
For now, continue using the current page and event submission process (freeze period dates to be advised).
If you have any questions, please contact halo@digital.ox.ac.uk
Reactive Trade-Offs: The Balance Between Aldehyde Detoxification and Ferroptosis Resistance
All cells must continuously manage reactivity – the chemistry that sustains life but also threatens it. Endogenous aldehydes such as formaldehyde are unavoidable byproducts of essential metabolism that challenge genome integrity, while uncontrolled lipid peroxidation can lead to ferroptotic cell death when antioxidant capacity becomes compromised. Both stresses are mainly handled by the same nucleophilic molecule: glutathione, creating a fundamental trade-off that must be resolved. In this lecture, I will discuss how cancer cells rewire their nucleophilic metabolism to navigate this conflict, prioritizing aldehyde detoxification or ferroptosis resistance according to their oncogenic landscape.
Date:
11 December 2025, 13:00
Venue:
MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details:
WIMM Seminar Room
Speaker:
Professor Lucas Pontel (Josep Carreras Leukaemia Research Institute (IJC))
Organising department:
MRC Molecular Haematology Unit
Organisers:
Beatriz Hirt-Font (University of Oxford, MRC Weatherall Institute of Molecular Medicine),
Emma Butterfield (MRC Weatherall Institute of Molecular Medicine),
Fiona Lambert (University of Oxford, MRC Weatherall Institute of Medicine)
Organiser contact email address:
beatriz.hirt-font@imm.ox.ac.uk
Host:
Prof Ketan Patel (University of Oxford)
Part of:
Molecular Haematology Unit, WIMM
Booking required?:
Not required
Cost:
Free
Audience:
Members of the University only
Editor:
Beatriz Hirt-Font
