OxTalks is Changing
Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
Regulation of ATP Production by Mitochondria
Cardiac ventricular myocytes work continuously but have minimal intracellular energy reserves sufficient for less than 30 seconds of work. To compensate for this energetic vulnerability, rapid and accurate real-time ATP production is essential, regulated by a stringent feedback-control system. Half of the required feedback-control system has been elucidated and updated recently showing how cellular and mitochondrial [Ca2+] control mitochondrial ATP production. Here we present critical new information on the second half of the feedback-control system which senses the amounts of energy consumed and carbon-based food-stock processed by mitochondria to synthesize ATP. We show that the pivotal new sensor that enables this process is soluble adenylyl cyclase, which resides in the mitochondrial intermembrane space and drives additional ATP production by mitochondria through the activation of a novel signaling cascade.
Date:
14 February 2025, 13:00
Venue:
Sherrington Library, off Parks Road OX1 3PT
Venue Details:
Sherrington Building
Speaker:
Dr Liron Boyman (DPAG, University of Oxford)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organisers:
Dr Mootaz Salman (DPAG, University of Oxford),
Associate Professor Samira Lakhal-Littleton (DPAG, University of Oxford)
Organiser contact email address:
events@dpag.ox.ac.uk
Host:
Professor David Paterson (DPAG, University of Oxford)
Part of:
DPAG Head of Department Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Hannah Simm
