OxTalks is Changing
On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
Regulation of ATP Production by Mitochondria
Cardiac ventricular myocytes work continuously but have minimal intracellular energy reserves sufficient for less than 30 seconds of work. To compensate for this energetic vulnerability, rapid and accurate real-time ATP production is essential, regulated by a stringent feedback-control system. Half of the required feedback-control system has been elucidated and updated recently showing how cellular and mitochondrial [Ca2+] control mitochondrial ATP production. Here we present critical new information on the second half of the feedback-control system which senses the amounts of energy consumed and carbon-based food-stock processed by mitochondria to synthesize ATP. We show that the pivotal new sensor that enables this process is soluble adenylyl cyclase, which resides in the mitochondrial intermembrane space and drives additional ATP production by mitochondria through the activation of a novel signaling cascade.
Date:
14 February 2025, 13:00
Venue:
Sherrington Library, off Parks Road OX1 3PT
Venue Details:
Sherrington Building
Speaker:
Dr Liron Boyman (DPAG, University of Oxford)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organisers:
Dr Mootaz Salman (DPAG, University of Oxford),
Associate Professor Samira Lakhal-Littleton (DPAG, University of Oxford)
Organiser contact email address:
events@dpag.ox.ac.uk
Host:
Professor David Paterson (DPAG, University of Oxford)
Part of:
DPAG Head of Department Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Hannah Simm
