What determines oncogenic competence?
This is a hybrid event - with the speaker attending in-person and viewable on Teams.
Oncogenes are not able to initiate tumours in all cellular contexts, a phenomenon referred to as oncogenic competence. Such competence depends on both cell-intrinsic programs (i.e. developmental and epigenetic state) as well as cell-extrinsic influences from the TME. To study this, we have developed zebrafish and human pluripotent stem cell models of melanoma. In the talk, I will discuss how convergence of intrinsic and extrinsic programs determines the likelihood of oncogenic transformation.
Date: 1 February 2024, 12:00
Venue: MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details: Seminar Room
Speaker: Professor Richard White (Oxford Ludwig Institute)
Organising department: MRC Weatherall Institute of Molecular Medicine
Organiser: Yasmine Saito (Weatherall Institute, University of Oxford)
Organiser contact email address: yasmine.saito@imm.ox.ac.uk
Host: Dr Ewa Gogola (University of Oxford)
Booking required?: Recommended
Booking email: seminar.admin@imm.ox.ac.uk
Audience: Members of the University only
Editor: Yasmine Saito