Inhibitory Immune Receptors or Immune Switches? The Role of “Inhibitory” KIR Immune Receptor Interactions with HLA-Class I in Chronic Inflammation and autoimmunity. Lessons from HLA-B27 and Inflammatory arthritis.
Status: This talk is in preparation - details may change
Chronic immune inflammation results from a failure to resolve persistent inflammatory stimuli. The resolution of inflammation is critically dependent on the carefully balanced orchestration of immune responses. “Inhibitory” KIR immune receptor interactions with HLA-class I have been implicated in diverse chronic inflammatory disorders including spondyloarthritis, Crohn’s disease and Pemphigus vulgaris. I will discuss how “inhibitory” KIR immune receptor interactions could promote inflammation using knowledge gained from our studies on HLA-B27 binding to immune receptors.
Date:
6 July 2015, 12:00 (Monday, 11th week, Trinity 2015)
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Dr Simon Kollnberger (Botnar Research Centre, NDORMS, University of Oxford)
Organising department:
Kennedy Institute of Rheumatology
Organisers:
Sandra Lock (University of Oxford, Kennedy Institute of Rheumatology),
Wulf Forrester-Barker (University of Oxford, Nuffield Dept of Orthopaedics Rheumatology and Musculoskeletal Sciences)
Host:
Dr Nikki Horwood (Kennedy Institute of Rheumatology, University of Oxford)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sandra Lock
