Seminar by Prof Paul Klenerman 'Taking Tmic'
This seminar will be held virtually via Zoom. This seminar is open only to members of Oxford University, register with a valid Oxford University email address at https://medsci.zoom.us/meeting/register/tJEqd-qgrTIpHtaMzBjKNK4BCAeb5Bp2P5Au
Tissues such as the gut and liver are enriched for “unconventional” or innate-like T cells. These cells manage to balance the competing demands of responding to microbes when they are dangerous/invasive, but otherwise maintaining a healthy homeostasis with commensals, using a combination of signals from their TCR and from cytokines. MAIT cells are one example of such cells. In this talk, I’ll discuss a new version of unconventional or innate-like behaviour shown by CD4+ T cells found in the human gut and their parallels in mice. These commensal-reactive, innate-like cells are restricted by MHC Class II and are currently termed “Tmic” cells. I’ll introduce this work which was a collaboration between the Kennedy and the TGU and discuss the implications in health and disease.
31 January 2022, 12:00 (Monday, 3rd week, Hilary 2022)
This seminar is open only to members of Oxford University, register using a valid Oxford University email address https://medsci.zoom.us/meeting/register/tJEqd-qgrTIpHtaMzBjKNK4BCAeb5Bp2P5Au
Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Ellen Mobbs (Kennedy Institute of Rheumatology),
Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
Prof Chris Buckley (Kennedy Institute of Rheumatology)
Kennedy Institute Seminars
Members of the University only