Seminar by Prof Paul Klenerman 'Taking Tmic'
This seminar will be held virtually via Zoom. This seminar is open only to members of Oxford University, register with a valid Oxford University email address at
Tissues such as the gut and liver are enriched for “unconventional” or innate-like T cells. These cells manage to balance the competing demands of responding to microbes when they are dangerous/invasive, but otherwise maintaining a healthy homeostasis with commensals, using a combination of signals from their TCR and from cytokines. MAIT cells are one example of such cells. In this talk, I’ll discuss a new version of unconventional or innate-like behaviour shown by CD4+ T cells found in the human gut and their parallels in mice. These commensal-reactive, innate-like cells are restricted by MHC Class II and are currently termed “Tmic” cells. I’ll introduce this work which was a collaboration between the Kennedy and the TGU and discuss the implications in health and disease.
Date: 31 January 2022, 12:00 (Monday, 3rd week, Hilary 2022)
Venue: This seminar is open only to members of Oxford University, register using a valid Oxford University email address
Speaker: Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Ellen Mobbs (Kennedy Institute of Rheumatology), Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
Host: Prof Chris Buckley (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url:
Audience: Members of the University only
Editors: Elizabeth Thompson, Ellen Mobbs