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Seminar by Prof Paul Klenerman 'Taking Tmic'
This seminar will be held virtually via Zoom. This seminar is open only to members of Oxford University, register with a valid Oxford University email address at https://medsci.zoom.us/meeting/register/tJEqd-qgrTIpHtaMzBjKNK4BCAeb5Bp2P5Au
Tissues such as the gut and liver are enriched for “unconventional” or innate-like T cells. These cells manage to balance the competing demands of responding to microbes when they are dangerous/invasive, but otherwise maintaining a healthy homeostasis with commensals, using a combination of signals from their TCR and from cytokines. MAIT cells are one example of such cells. In this talk, I’ll discuss a new version of unconventional or innate-like behaviour shown by CD4+ T cells found in the human gut and their parallels in mice. These commensal-reactive, innate-like cells are restricted by MHC Class II and are currently termed “Tmic” cells. I’ll introduce this work which was a collaboration between the Kennedy and the TGU and discuss the implications in health and disease.
Date:
31 January 2022, 12:00
Venue:
This seminar is open only to members of Oxford University, register using a valid Oxford University email address https://medsci.zoom.us/meeting/register/tJEqd-qgrTIpHtaMzBjKNK4BCAeb5Bp2P5Au
Speaker:
Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Ellen Mobbs (Kennedy Institute of Rheumatology),
Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
ellen.mobbs@kennedy.ox.ac.uk
Host:
Prof Chris Buckley (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Required
Booking url:
https://medsci.zoom.us/meeting/register/tJEqd-qgrTIpHtaMzBjKNK4BCAeb5Bp2P5Au
Audience:
Members of the University only
Editors:
Elizabeth Thompson,
Ellen Mobbs
