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OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
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Illuminating the private life of cyclic AMP in the primary cilium
The primary cilium is a cell surface organelle that has been described as a signaling hub because it concentrates a large number of specialized signaling components within its tiny volume. In particular, primary cilia sequester diverse GPCRs connected to cAMP signaling, such as receptors for dopamine (D1R), serotonin (5-HT6) and somatostatin (SSTR3). Interest in ciliary cAMP signaling has expanded greatly following the discovery that cAMP-dependent protein kinase A (PKA) is among the kinases regulating the ciliary transcription factors that mediate canonical Hedgehog (Hh) signaling (i.e. through phosphorylation of Gli transcription factors). This presentation will describe optical approaches for interrogating the cAMP signaling microdomain of the primary cilium. Our direct organelle measurements challenge some of the assumptions about the nature of cAMP signaling in the ciliary space and suggest possible roles for GPCRs in Hh regulation.
Date:
29 March 2019, 13:00
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Sherrington Room
Speaker:
Professor Aldebaran Hofer (Harvard Medical School Boston, USA)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organisers:
Professor Maike Glitsch (DPAG, University of Oxford),
Professor Anant Parekh (University of Oxford)
Organiser contact email address:
anant.parekh@dpag.ox.ac.uk
Hosts:
Professor Maike Glitsch (DPAG, University of Oxford),
Professor Anant Parekh (University of Oxford)
Part of:
Cell Physiology Theme Guest Speakers (DPAG)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Talitha Smith
