3D microfluidic liver cultures are a physiological model to study Hepatitis B virus
Please arrive 5 minutes before the Seminar begins to gain building access
The in vitro models to study of Hepatitis B virus (HBV) are very limited and only poorly mimic physiological virus-host interaction. Recently, we have demonstrated that 3D microfluidic cultures are a powerful tool to study HBV within its natural target cell. These cultures allow the long-term survival of primary human hepatocyte, in the presence and in the absence of Kupffer cells, are highly susceptible to HBV and recapitulate all steps of the HBV life cycle. In addition to mimicking host responses observed in HBV-infected patients, these advantages enable the evaluation of sequential and long-term antiviral treatments targeting any step of the viral cycle and the study of innate immune responses to HBV by hepatocytes and other non-parenchymal cells in the liver.
Date:
2 May 2018, 12:00 (Wednesday, 2nd week, Trinity 2018)
Venue:
Medawar Building, off South Parks Road OX1 3SY
Venue Details:
Level 30 Seminar Room
Speaker:
Ana Maria Ortega-Prieto (Imperial College London)
Organising department:
Nuffield Department of Clinical Medicine
Organisers:
Dr Proochista Ariana (University of Oxford),
Professor Sunetra Gupta (University of Oxford),
Prof Lynn Dustin (NDORMS)
Organiser contact email address:
andrea.kastner@zoo.ox.ac.uk
Host:
Prof Lynn Dustin (NDORMS)
Part of:
Peter Medawar Building Seminars
Topics:
Booking required?:
Not required
Cost:
FREE
Audience:
The Scientific Community
Editors:
Lynn Dustin,
Thomas Johnson
