Perfecting DSB Repair on Transcribed Chromatin
Synopsis: DNA double-strand breaks (DSBs) induce transient pausing of transcription on flanking chromatin. Although this phenomenon is driven by ATM and poly (ADP-ribose) polymerase activities, the molecular determinants that couple transcriptional silencing and DSB repair remain unclear. Mechanistically how gene expression resumes upon completion of DNA repair also warrants scrutiny. This talk will highlight our recent effort to delineate DSB response pathways that fine-tune local transcriptional activities to preserve genome integrity.
7 November 2019, 13:15 (Thursday, 4th week, Michaelmas 2019)
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Dr Michael Huen (LKS Faculty of Medicine The University of Hong Kong)
Wellcome Trust Centre for Human Genetics
Isabel Schmidt (University of Oxford, Wellcome Centre for Human Genetics)
Members of the University only