[CorTalk] Neuro-glia-immune mechanisms of synapse loss in neurodegeneration
One important question is how microglia detect and determine which synapses to eliminate and which ones to spare. Emerging data suggest that microglial cell states, including the synapse phagocytosing ones, are influenced not only by changes in neuronal activity but also by surrounding astrocytes and perivascular macrophages. Further, cell-cell crosstalk influencing synaptic fate can also involve adaptive immune signalling along brain borders. I will discuss potential modulators of microglia-synapse interactions with relevance in neurodegenerative diseases.
Date: 30 April 2025, 16:00
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Blakemore Lecture Theatre, DPAG
Speaker: Soyon Hong (UCL)
Organising department: MRC Brain Network Dynamics Unit
Organiser: Sasha Tinelli (University of Oxford)
Organiser contact email address: sasha.tinelli@chch.ox.ac.uk
Host: Sasha Tinelli (University of Oxford)
Booking required?: Not required
Audience: Public
Editor: Sasha Tinelli