Alzheimer’s disease (AD) is the most common dementia affecting 35-50 million individuals worldwide. Although it was discovered over 110 years ago, there is still no cure for AD despite decades of enormous effort. The big challenges right now are 1) the necessity for the unveiling of more of the molecular mechanisms leading to the development of AD; 2) creation of easily accessible and affordable approaches to identify individuals with early AD to facilitate earlier intervention and treatment; 3) strategies or treatments to delay, slow down or prevent AD are urgently needed; and 4) the necessity for accellerating the development of effective anti-AD drugs or therapies using modern techniques (e.g., CRISPR-Cas9 and artificial intelligence/AI). After the success of the 1st NO-AD meeting (website here and recorded videos here) on the 25th Nov 2020, we are pleased to open the 2nd NO-AD meeting on the 20th Oct. 2021 to be jointly organized by The University of Olso (UiO, Norway) and Akershus University Hospital (Ahus, Norway), The University of Oxford (Oxford, UK), and Charles University (CU, Czech Republic).