OxTalks is Changing
OxTalks will soon be transitioning to Oxford Events (full details are available on the Staff Gateway). A two-week publishing freeze is expected in early Hilary to allow all events to be migrated to the new platform. During this period, you will not be able to submit or edit events on OxTalks. The exact freeze dates will be confirmed as soon as possible.
If you have any questions, please contact halo@digital.ox.ac.uk
Lister Institute Research Prize Lecture: Genome maintenance versus genome diversification: mechanisms governing the fate of DNA breaks
Synopsis: “DNA double-strand breaks (DSBs) are highly toxic and their accurate repair is essential for the prevention of human disease and cancer. However, in developing B and T lymphocytes, mutagenic DSB repair is instead favoured and mediates genetic recombination within antibody/B cell and T cell receptor genes, the result of which creates diversity in immune repertoire. To cope with this intrinsic discrepancy in desired DNA repair outcome between different contexts and tissue types, cells have evolved complex regulatory systems that maintain an appropriate equilibrium between competing DNA repair pathways, and that ensure DNA breaks are appropriately resolved. This talk will focus on my groups’ recent research into the molecular mechanisms that underpin a cell’s ability to select between accurate and mutagenic DNA repair pathways, and will describe how understanding these processes can inform on the molecular basis of cancer and its response to therapy
Date:
10 March 2020, 12:00
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Seminar Rooms A&B
Speaker:
Dr Ross Chapman (University of Oxford)
Organising department:
Nuffield Department of Clinical Medicine
Organiser:
Kathryn Smith (Nuffield Department of Medicine)
Part of:
NDM Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Kathryn Smith
