OxTalks is Changing
OxTalks will soon be transitioning to Oxford Events (full details are available on the Staff Gateway). A two-week publishing freeze is expected in early Hilary to allow all events to be migrated to the new platform. During this period, you will not be able to submit or edit events on OxTalks. The exact freeze dates will be confirmed as soon as possible.
If you have any questions, please contact halo@digital.ox.ac.uk
Characterizing the role of HLA in immune-mediated traits in global populations
This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJItcumrrD4sE9KMWMn6kKrNRCdNyepVnmys
Defining plausible causal variation by fine-mapping can be more effective in multi-ethnic genetic studies, particularly in regions such as the MHC with highly population-specific structure. To enable such studies, we constructed a large (N=21,546) high resolution HLA reference panel spanning five global populations based on whole-genome sequences. We jointly analyzed HIV-1 viral load GWAS data from three diverse populations. Our analysis pinpointed the MHC association to three amino acid positions (97, 67 and 156) marking three consecutive pockets within the HLA-B peptide binding groove, explaining 12.9% of trait variance, and obviating effects of previously reported associations from population-specific HIV studies.
Date:
28 October 2020, 14:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJItcumrrD4sE9KMWMn6kKrNRCdNyepVnmys
Speaker:
Dr Yang Luo (Harvard Medical School)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Jennifer Pope (Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
jennifer.pope@kennedy.ox.ac.uk
Host:
Professor Mike Dustin (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Required
Booking url:
https://zoom.us/meeting/register/tJItcumrrD4sE9KMWMn6kKrNRCdNyepVnmys
Audience:
Public
Editor:
Jennifer Pope
