Characterizing the role of HLA in immune-mediated traits in global populations
This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJItcumrrD4sE9KMWMn6kKrNRCdNyepVnmys
Defining plausible causal variation by fine-mapping can be more effective in multi-ethnic genetic studies, particularly in regions such as the MHC with highly population-specific structure. To enable such studies, we constructed a large (N=21,546) high resolution HLA reference panel spanning five global populations based on whole-genome sequences. We jointly analyzed HIV-1 viral load GWAS data from three diverse populations. Our analysis pinpointed the MHC association to three amino acid positions (97, 67 and 156) marking three consecutive pockets within the HLA-B peptide binding groove, explaining 12.9% of trait variance, and obviating effects of previously reported associations from population-specific HIV studies.
Date: 28 October 2020, 14:00 (Wednesday, 3rd week, Michaelmas 2020)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJItcumrrD4sE9KMWMn6kKrNRCdNyepVnmys
Speaker: Dr Yang Luo (Harvard Medical School)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Jennifer Pope (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address: jennifer.pope@kennedy.ox.ac.uk
Host: Professor Mike Dustin (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://zoom.us/meeting/register/tJItcumrrD4sE9KMWMn6kKrNRCdNyepVnmys
Audience: Public
Editor: Jennifer Pope