Chromatin biology and epigenetics is a fast growing field at the frontier of modern biology, with considerable impact on understanding of fundamental mechanisms in human health and disease. The symposium ‘Epigenetic Mechanisms in Health and Disease’ aims to bring together clinical and non-clinical scientists at the forefront of epigenetics and chromatin biology and inﬂammation to discuss the latest advances in the field. We aim to explore future trends in epigenetics and related ﬁelds of gene regulation, development, molecular recognition and signalling, with an emphasis on prospects of translation into clinical applications. On the first day the focus will be on the latest advances in inflammation followed by epigenetics highlights on the second day. The symposium is followed by a medicinal chemistry workshop centered on epigenetic target classes on the third day.