Early innovation in drug platforms: antibodies and bicyclic peptides

Sir Gregory Winter FRS is Master of Trinity College Cambridge and was until recently a member of the Medical Research Council’s Laboratory of Molecular Biology (LMB) in Cambridge. He is a scientist, inventor and entrepreneur. He is a pioneer of the science of protein engineering, and in particular of technologies for making pharmaceutical antibodies. Such antibodies have proved useful for treatment of cancer and immune disorders, and now comprise many of the world’s top selling pharmaceutical drugs. In order to see his technologies applied, Sir Gregory founded Cambridge Antibody Technology and Domantis (both acquired in 2006 by AstraZeneca and GSK respectively), and most recently Bicycle Therapeutics, which is developing bicyclic peptides with chemical warheads for treatment of cancer.