Polycomb Repressor Proteins in Cancer

Cancer cells are now known to have epigenetic as well as genetic alterations. Polycomb group proteins are involved in chromatin modification and are crucial in many cell fate decisions. Adrian Bracken’s group is investigating whether dysregulation of Polycomb function is involved in tumorigenesis. He is also studying interactions between Polycomb proteins and other transcriptional regulators, in the context of stem cells and differentiation pathways as well as in cancer.