GUEST SPEAKER Professor Adrian Hobbs, Professor of Cardiovascular Pharmacology QMUL : ‘Pivotal Cardiovascular Homeostatic role for C-type natriuretic peptide’

‘C-type natriuretic peptide (CNP) is highly concentrated in endothelial cells but its physiological role(s) in the cardiovascular system are poorly defined. Prof. Hobbs’ lab has a long-standing interest in the physiology, pathophysiology and pharmacology of this peptide, and developed novel pharmacological and genetic tools to dissect the key processes CNP regulates in both the vasculature and the heart.’ His work has identified a fundamental vasoprotective role of endothelium-derived CNP in modulating vascular tone, blood vessel morphology, the reactivity of leukocytes and platelets, and the development of atheroma and aneurism. More recently, these approaches have revealed critical physiological and pathological roles of CNP in the myocardium.’