Associative representations in the rodent lateral orbitofrontal cortex: Acting on your values.
The orbitofrontal cortex (OFC) has received a lot of attention in the past decade, and has been implicated in a wide range of functional roles such as response inhibition, encoding predicted value, encoding the sensory properties of expected outcomes, and encoding “latent states” in model based reinforcement learning. These hypotheses are predominantly modelled on deficits in outcome devaluation, and reversal learning following disruption to OFC function, while leaving initial acquisition learning intact. However, all of these key findings have had replication issues. I will present a series of experiments that explores the role of the rodent lateral OFC in (1) outcome devaluation, (2) reversal learning, and (3) simple Pavlovian learning procedures. These experiments reveal the importance of the rodent lateral OFC in a specific associative pathway allowing current values to update Pavlovian actions. Furthermore, a functional dissociation is found between anterior and posterior subregions of the lateral OFC. These findings also provide a possible solution to the often contradictory findings in the OFC literature that involve data taken from a range of species (rodents, non-human primates, and humans), using different experimental protocols, and often involving comparing across different orbital sub regions
Date: 14 November 2017, 13:00 (Tuesday, 6th week, Michaelmas 2017)
Venue: Biology South Parks Road, South Parks Road OX1 3RB
Venue Details: Schlich Theatre
Speaker: Dr Marios Panagi (University of Oxford )
Organising department: Department of Experimental Psychology
Organiser: Nils Kolling (Junior Research Fellow, Experimental Psychology, University of Oxford)
Organiser contact email address: nils.kolling@psy.ox.ac.uk
Host: Anna Huber (University of Oxford)
Booking required?: Not required
Audience: Members of the University only
Editor: Stephanie Mcclain