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Serotonergic inputs innervate nearly the entire brain and broadly influence behavior, but how serotonin shapes neural circuit function at the synaptic and cellular levels remain poorly understood. The Swanger lab has discovered cell-type-specific mechanisms by which serotonin regulates communication between the hippocampus and anterior nucleus of the thalamus. This seminar will discuss how serotonin influences excitation and inhibition within this circuitry as well as the lab’s ongoing work investigating how targeting serotonin signaling counteracts circuit hyperexcitability in an epilepsy mouse model.
