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Identification of Disease Mechanisms and Potential Therapeutic Targets for ALS and FTD Using Stem Cells
We have used patient-specific stem cell technology to uncover a surprising interplay between gain- and loss-of-function disease mechanisms in the most common form of ALS and FTD, caused by a repeat expansion mutation in C9ORF72. In addition, we have used high-throughput chemical screens on patient-derived neurons to identify novel therapeutic targets for C9ORF72 and sporadic ALS. Recently, we have developed a systematic approach for the identification of gene variants that cause sporadic ALS and are using it to investigate potential new ALS genes with key roles in proteostasis.
Date:
16 April 2018, 11:00
Venue:
Le Gros Clark Building, off South Parks Road OX1 3QX
Venue Details:
Lecture Theatre
Speaker:
Justin Ichida (USC Keck School of Medicine Los Angeles)
Organiser:
Francis Szele (DPAG)
Organiser contact email address:
francis.szele@dpag.ox.ac.uk
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Francis Szele
