DNA repair, NAD+ and mitophagy in neurodegeneration and ageing
Ageing is emerging as a universal problem bringing formidable socioeconomic challenges. Studies on the mechanisms of ageing will facilitate our understanding of the process and will generate potential preventive strategies. Since no single ageing theory can satisfactorily explain all aspects of the ageing process, an integration of multiple theories on ageing is favored. The speaker will describe his latest studies on how two classical ageing hypotheses, persistent DNA damage and mitochondrial dysfunction, converge to explain premature ageing symptoms and contribute to neurological phenotypes in a series of ageing laboratory models. Emerging evidence suggests a critical role for DNA damage signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. The interconnected roles of DNA damage, NAD+, and mitophagy will be explored in relation to ageing and neurodegenerative diseases, especially Alzheimer’s disease.
Date: 5 April 2016, 13:00
Venue: MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details: Seminar Room
Speaker: Dr Evandro Fang (National Institutes on Aging, Bethesda, MD, USA)
Organising department: MRC Weatherall Institute of Molecular Medicine
Organisers: Penny Berry (University of Oxford, Department of Oncology, Weatherall Institute of Molecular Medicine), Liz Rose (University of Oxford, Weatherall Institute of Molecular Medicine)
Organiser contact email address: penny.berry@oncology.ox.ac.uk
Hosts: Dr Peter McHugh (University of Oxford, Weatherall Institute of Molecular Medicine), Professor Doug Higgs (University of Oxford, Weatherall Institute of Molecular Medicine)
Part of: WIMM Occasional Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Penny Berry