Seminar by Dr Lizzy Rosser " How does gut-derived metabolite availability regulate B cell function in autoimmune arthritis"
The gastrointestinal tract is home to a multitude of commensal micro-organisms that co-develop with the host from birth to influence a wide range of physiological processes. These commensal organisms, collectively known as the gut-microbiota, are known to many control aspects of immune system development and function both directly and indirectly. This includes research from our laboratory showing that changes in the gut-microbiota and associated metabolites affects the balance between antibody-producing and regulatory B cell subsets in experimental models of autoimmunity. Further exploration of these signals in human arthritides across age (rheumatoid arthritis, juvenile idiopathic arthritis) could identify novel approaches to specifically target pathogenic B cell responses in both childhood and adult arthritis.
Date: 15 May 2023, 12:00 (Monday, 4th week, Trinity 2023)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Speaker: Dr Lizzy Rosser (UCL)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Ellen Mobbs (Kennedy Institute of Rheumatology), Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
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Host: Alexander Clarke (Kennedy Institute, University of Oxford)
Part of: Kennedy Institute Seminars
Booking required?: Required
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Audience: Members of the University only
Editors: Ellen Mobbs, Lola Chaplin