Seminar by Dr Lizzy Rosser " How does gut-derived metabolite availability regulate B cell function in autoimmune arthritis"
The gastrointestinal tract is home to a multitude of commensal micro-organisms that co-develop with the host from birth to influence a wide range of physiological processes. These commensal organisms, collectively known as the gut-microbiota, are known to many control aspects of immune system development and function both directly and indirectly. This includes research from our laboratory showing that changes in the gut-microbiota and associated metabolites affects the balance between antibody-producing and regulatory B cell subsets in experimental models of autoimmunity. Further exploration of these signals in human arthritides across age (rheumatoid arthritis, juvenile idiopathic arthritis) could identify novel approaches to specifically target pathogenic B cell responses in both childhood and adult arthritis.
15 May 2023, 12:00 (Monday, 4th week, Trinity 2023)
Kennedy Institute of Rheumatology, Headington OX3 7FY
Dr Lizzy Rosser (UCL)
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Ellen Mobbs (Kennedy Institute of Rheumatology),
Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
Alexander Clarke (Kennedy Institute, University of Oxford)
Kennedy Institute Seminars
Members of the University only