Title TBC
Research
1. Developing a complete isoform view of biology
It is well established that the vast majority of mammalian genes can generate multiple isoforms. Yet, the majority of publications considers a “one-gene-one-protein” model, in which each gene’s expression is represented by a single number. If we take the view that genes can talk – the “one-gene-one-number” approach is akin to judging each gene by how much it talks; not by what it is actually saying. We have made considerable progress (both on the informatic and experimental side) on the way to actually judging genes by what-they-say, yet important challenges still remain to be conquered.
2. Isoform usage patterns in the central nervous system
All cells in a mammalian brain have (approximately) the same genome – yet they have unique ways of interpreting this genome by producing characteristic expression patterns of genes – and unique sets of RNA and protein isoforms. We aim at finding these characteristic isoforms of a variety of cell types and establish if and how they are linked to the cell’s function.
3. Isoform switches associated with development & aging
Complex organs such as the brain change dramatically first during development and then again during the aging process – despite only relatively small changes in DNA sequence. We aim at using our unique set of technological insights to understand how isoform usage is affected, both during development and aging – and at distinguishing causes from consequences.
4. Isoform usage in developmental disorders and neurodegenerative disease
Both developmental and neurodegenerative diseases have devastating consequences for the affected individuals. Yet a true isoform view of these diseases is lacking in almost all cases and may advance our understanding of the molecular causes for disease
Date:
4 July 2025, 15:00
Venue:
IMS-Tetsuya Nakamura Building, Roosevelt Dr, Headington OX3 7TY
Venue Details:
IDRM Seminar Rooms 1&2 or via Teams link
Speaker:
Associate Professor Hagen Tilgner (Weill Cornell Medicine, NYC)
Organising department:
Medical Sciences Division
Host:
Prof. Carlo Rinaldi (University of Oxford)
Booking required?:
Recommended
Booking url:
https://forms.office.com/e/vGBm36DMpB
Audience:
Members of the University only
Editors:
Amanda Nicolle,
Joe Day
