OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Developing integrative algorithms to accelerate microbiome-based therapies and diagnostics
In Person
DNA sequencing has transformed our understanding of the microbiome in health and disease, yet microbiome-based interventions remain scarce in clinical practice. One challenge lies in reference-based computational pipelines, which report numerous false-positive species, compromising accuracy and reproducibility across cohorts (“garbage in, garbage out”). Fourier transform-based algorithms enhance species-level annotations and minimize contamination signals. Moreover, software that integrates longitudinal DNA, RNA, and metabolomics data enables monitoring early bacterial stress-sensing. Since stress responses are often stimulus-specific, transcriptional programs of bacteria point to the stressors itself and may inform targeted therapies; for example, supplementing commensal strains that consume gluconate decolonizes antibiotic-resistant Enterobacteriaceae through ecological competition.
Date:
21 February 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Dr Marie-Madlen Pust (Massachusetts General Hospital & Harvard University)
Organising department:
Kennedy Institute of Rheumatology
Organiser:
Magdalena Gross
Host:
Professor Fiona Powrie (Kennedy Institute of Rheumatlogy)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Magdalena Gross
