Covalent DNA-protein crosslinks (DPCs) are highly detrimental DNA lesions that interfere with essential chromatin transactions such as replication and transcription. The topic of the seminar will be insights into regulation of DPC repair obtained using novel assays to monitor DPC cleavage in vitro and in human cells.
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Julian did his PhD with Stefan Jentsch at the Max-Planck Institute of Biochemistry, Martinsried, Germany followed by postdoctoral research with Simon Boulton at the Francis Crick Institute. In 2017 Julian set up his own lab at LMU Munich where he studies the causes and consequences of covalent DNA-protein crosslinks.
