Congenital heart defects (CHD) constitute almost a third of all congenital anomalies. Despite the challenge of underdiagnosis, sub-Saharan Africa has the highest birth prevalence of CHD in the world, and low- and middle-income countries contribute 77% of all global deaths due to CHD. In this webinar we discuss the challenges of CHD in sub-Saharan Africa and present recent prevalence, experience and best practice from the region, including the value of CHD screening with pulse oximetry in low resource, primary care settings.