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Modelling infectious diseases within-host
During the talk I will describe my research on host-pathogen interactions during lung infections. Various modelling approaches have been used, including a hybrid multiscale individual-based model that we have developed, which simulates pulmonary infection spread, immune response and treatment within in a section of human lung. The model contains discrete agents which model the spatio-temporal interactions (migration, binding, killing etc.) of the pathogen and immune cells. Cytokine and oxygen dynamics are also included, as well as Pharmacokinetic/Pharmacodynamic models, which are incorporated via PDEs. I will also describe ongoing work to develop a continuum model, comparing the spatial dynamics resulting from these different modelling approaches. I will focus in the most part on two infectious diseases: Tuberculosis and COVID-19.
Date:
23 May 2025, 11:00
Venue:
Mathematical Institute, Woodstock Road OX2 6GG
Venue Details:
L2
Speaker:
Dr Ruth Bowness (University of Bath)
Organising department:
Mathematical Institute
Organiser:
Sara Jolliffe (University of Oxford)
Organiser contact email address:
jolliffe@maths.ox.ac.uk
Hosts:
Dr Robin Thomspon (University of Oxford),
Dr Eamonn Gaffney (University of Oxford)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sara Jolliffe
