Imaging genomics of functional brain networks
During rest, brain activity is intrinsically synchronized between different brain regions, forming networks of coherent activity. These ‘resting-state’ functional networks (FNs), consisting of multiple regions widely distributed across lobes and hemispheres, appear to be a fundamental theme of neural organization in mammalian brains.

Previous work has mostly focused on polymorphisms in candidate genes, or used a twin study approach to demonstrate heritability of aspects of resting-state connectivity. The recent availability of high spatial resolution post-mortem brain gene expression datasets, together with several large-scale imaging genetics datasets, which contain joint in-vivo functional brain imaging data and genotype data for several hundred subjects, opens intriguing data analysis avenues.

Using novel cross-modal graph-based statistics, we show that functional brain networks defined with resting-state fMRI can be recapitulated using measures of correlated gene expression, and that the relationship is not driven by gross tissue types. The set of genes we identify is significantly enriched for certain types of ion channels and synapse-related genes. We validate results by showing that polymorphisms in this set significantly correlate with alterations of in-vivo resting-state functional connectivity in a group of 259 adolescents. We further validate results on another species by showing that our list of genes is significantly associated with neuronal connectivity in the mouse brain. These results provide convergent, multimodal evidence that resting-state functional networks emerge from the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.
Date: 20 April 2016, 14:00 (Wednesday, 0th week, Trinity 2016)
Venue: Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details: Seminar Room A
Speaker: Dr Jonas Richiardi (Standford University and University of Geneva)
Organising department: Wellcome Trust Centre for Human Genetics
Organisers: Rosie Butler (University of Oxford, Wellcome Trust Centre for Human Genetics), Christine Webb (University of Oxford, Wellcome Trust Centre for Human Genetics), Susan Wilson (University of Oxford, Wellcome Trust Centre for Human Genetics), Professor Gil McVean (University of Oxford)
Organiser contact email address: mcvean@well.ox.ac.uk
Host: Professor Gil McVean (University of Oxford)
Part of: WHG Seminars
Topics:
Booking required?: Not required
Audience: Members of the University only
Editor: Emma Jones