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Tissue Regulation at the Crossroads: What Autoimmunity Teaches Us about Immune-Mediated Damage
This is a hybrid event - with the speaker attending in-person and viewable on Teams.
Tissue destruction in immune-mediated disease requires more than the presence of antigen-specific lymphocytes. Lessons from type 1 diabetes and celiac disease show that loss of tolerance—marked by autoreactive or dietary antigen–specific Th1 responses—is necessary but not sufficient for pathology. The magnitude of the CD4⁺ T-cell response, and the signals that amplify it, are decisive because they provide the “license” enabling cytotoxic CD8⁺ T cells (CTLs) to kill. Notably, antigen-specific CTLs can persist in tissues without causing injury unless they receive additional cues. These licensing signals differ from those in lymph nodes and include stress-induced non-classical MHC ligands, NK receptor engagement, and cytokines such as IL-15. This framework helps explain why tumor-specific CTLs often fail to clear cancers and suggests that, beyond checkpoint inhibition, therapies must also target the pathways that license CTLs to execute tissue destruction.
Date:
20 November 2025, 12:00
Venue:
MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details:
Seminar Room
Speaker:
Professor Bana Jabri (University of Chicago)
Organising department:
MRC Weatherall Institute of Molecular Medicine
Organiser:
Yasmine Saito (Weatherall Institute, University of Oxford)
Organiser contact email address:
seminar.admin@imm.ox.ac.uk
Host:
Professor Alison Simmons (University of Oxford)
Part of:
WIMM THURSDAY SEMINARS
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Yasmine Saito
