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"Portals and DNA packaging in tailed bacteriophages and herpesviruses"
Tailed bacteriophages (order Caudovirales) are characterised by an icosahedral capsid, which encloses a double-stranded DNA genome. These phages and herpesviruses share a common assembly pathway for prohead formation and genome packaging. In both viruses, DNA incorporation and ejection is mediated by a machinery built by similar components, including the portal protein and a motor protein complex called terminase, which provides the energy for DNA translocation and has nuclease activity. The portal is a large oligomeric ring-shaped protein located at a unique pentameric vertex of the capsid. It acts as an initiator for capsid assembly and it is also a critical part of the DNA packaging and ejection machinery. In phages, the portal is also involved in tail assembly.
Using X-ray crystallography and high-resolution cryo-electron microscopy, we have solved the structure of a bacteriophage portal, in different conformations, and a tail complex. Our findings point to a molecular mechanism for DNA retention and ejection. A herpesvirus terminase subunit and a portal have also been solved and will be compared with their phage equivalent parts.
Date:
10 July 2019, 16:00
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Meeting rooms A & B
Speaker:
Prof Miquel Coll ( IRB Barcelona)
Organising department:
Wellcome Trust Centre for Human Genetics
Organiser contact email address:
strubiadmin@strubi.ox.ac.uk
Part of:
Strubi seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Agata Krupa
