Targeting subcellular trafficking pathways for the design of therapeutic antibodies

Sally Ward completed her Ph.D. in the Department of Biochemistry at Cambridge University in the laboratory of Professor David Ellar. From 1988 to 1990, she carried out research on antibody repertoire technology in Sir Greg Winter’s laboratory at the MRC Laboratory of Molecular Biology in Cambridge. In 1990 she joined the University of Texas Southwestern Medical Center in Dallas as an Assistant Professor, and was appointed to the Paul and Betty Meek-FINA Professorship in Molecular Immunology at the same institution in 2004.

Sally was recently appointed Director of Translational Immunology and Professor of Molecular Immunology at the Centre for Cancer Immunology in Southampton, U.K. Her interdisciplinary research is carried out in collaboration with Raimund Ober and involves the use of a combination of protein engineering, fluorescence microscopy and in vivo studies to develop antibody-based technologies for the therapy of human disease. These approaches have been successfully translated to the clinic to increase the longevity of therapeutic antibodies and treat antibody-mediated autoimmunity.