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Axo-spinous communication between the cortex and thalamus
Spines are ubiquitous morpho-functional elements of excitatory synaptic transmission and plasticity in the neocortex. Whether functional spines are also present in the thalamus is currently unclear. Here I demonstrate that layer 5 cortico-thalamic terminals arising from several frontal cortical regions preferentially target functional spines in the thalamus via variable and complex synapses. These axo-spinous L5-thalamic connections are surprisingly powerful, able to selectively recruit a subset of thalamic neuron and are involved in motor learning.
Date:
13 January 2026, 16:00
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Florence Buchanan Lecture Theatre
Speaker:
Professor László Acsády (Hungarian Research Network, Institute of Experimental Medicine)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Host:
Professor Zoltan Molnar (DPAG, University of Oxford)
Part of:
Neuroscience Theme Guest Speakers (DPAG)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Hannah Simm
