T cell communication goes viral-a role for extracellular vesicles in T cell help
please arrive 5 minutes early for entry
We recently discovered that T cells generate extracellular vesicles within the immunological synapse that are highly enriched in T cell antigen receptors. Recently, we developed new methods to document what other proteins are present and how they are localised within the extracellular vesicles, which we refer to as synaptic ectosomes. The newly identified proteins include the retroviral restriction factor tetherin (CD317) and the ligand for CD40 (CD154). I will present a new model for how these “virus” like particles help spread information in lymphoid tissues.
Date: 25 October 2017, 12:00 (Wednesday, 3rd week, Michaelmas 2017)
Venue: Medawar Building, off South Parks Road OX1 3SY
Venue Details: Level 30 conference room
Speaker: Professor Mike Dustin (Kennedy Institute of Rheumatology)
Organising department: Nuffield Department of Clinical Medicine
Organisers: Chris Willberg (NDM Experimental Medicine), Prof Lynn Dustin (NDORMS)
Part of: Peter Medawar Building Seminars
Booking required?: Not required
Audience: Members of the University only
Editors: Lynn Dustin, Rebecca Allen