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Protein Synthesis at Neuronal Synapses
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The complex morphology of neurons, with synapses located 100’s of microns from the cell body, necessitates the localization of important cell biological machines and processes within dendrites and axons.
Using expansion microscopy together with metabolic labeling we have discovered that both postsynaptic spines and presynaptic terminals exhibit rapid translation, which exhibits differential sensitivity to different neurotransmitters and neuromodulators.
In addition, we have explored the unique mechanisms neurons use to meet protein demands at synapses, identifying the transcriptome and translatome in the neuropil.
Date:
27 October 2020, 16:00
Venue:
Details on how to join will be distributed on the Cortex Club mailing list. Details on how to subscribe at https://cortexclub.com/join-us/
Speaker:
Prof Dr Erin Schuman (Max Planck Institute for Brain Research)
Organiser:
Cortex Club (University of Oxford)
Host:
Tara Diviney (University of Oxford)
Part of:
Cortex Club - Oxford Neuroscience Society
Booking required?:
Not required
Cost:
free
Audience:
Public
Editors:
Tara Diviney,
Jasper Hunt
