How has life begun, how was the world created, and what lied at the origin of the creation? Human procreation, especially the origin of life, was frequently the subject of speculation and analysis in medieval thought. Drawings of the uterus accompanied and supported these reflections about the development of life in female bodies. These were made by anonymous draughtsmen and illustrators of medieval manuscripts as well as known scholars and artists like Hildegard von Bingen, Opicinus di Canistris, Jerome Bosch, and Leonardo da Vinci. Analysing the thoughts embedded into these images illuminates the creativity of such connections between divine creation, human procreation and artistic creativity ignited through an exploration of the unknown and the unseen.