Building Basement Membranes: Secretion, Assembly and Role in Tissue Growth
Basement membranes (BMs) are polymers of matrix proteins underlying epithelia and surrounding organs in all animals. BMs and Collagen IV, their main component, are actually the key evolutionary innovations allowing the existence of tissues and the evolution of complex body plans in the Metazoa. In my laboratory, we are trying to understand the biology of tissues and BMs using the fruit fly Drosophila melanogaster as a model organism, mostly through genetics and cell biology approaches. During my talk, I will present our findings regarding the secretion of Collagen IV, the hierarchy of assembly of BM components and the developmental roles of BMs in mechanically shaping tissues and regulating tissue growth. I will also discuss results from my laboratory showing that Collagen IV can mediate intercellular adhesion through a novel form of matrix organization that we call CIVICs (Collagen IV Intercellular Concentrations). Finally, I will present recent data on how microtubule organization ensures proper Collagen release by secreting cells.
Date: 26 April 2018, 15:00 (Thursday, 1st week, Trinity 2018)
Venue: Sir William Dunn School of Pathology, South Parks Road OX1 3RE
Venue Details: EPA Seminar Room
Speaker: Dr Jose Pastor-Pareja (School of Life Sciences, Tsinghua University)
Organising department: Sir William Dunn School of Pathology
Organisers: Jo Peel (University of Oxford, Sir William Dunn School of Pathology), Omer Dushek (University of Oxford, Sir William Dunn School of Pathology, Wolfson College), Anton van der Merwe (Sir William Dunn School of Pathology), Melissa Wright (Sir William Dunn School of Pathology)
Organiser contact email address:
Host: Dr Alberto Baena (University of Oxford )
Part of: Dunn School of Pathology Research Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Melissa Wright