Cardioprotection in the setting of acute myocardial infarction: where do we stand in 2018?
Myocardial infarction due to coronary heart disease is the major cause of death in developed countries and a major determinant for the development of heart failure. Within the last 30 years there has been intense research into cardioprotective therapies capable of limiting cardiac damage due to infarction. However, despite a better comprehension of the molecular and cellular mechanisms triggered during the ischemic insult and further revascularization, and encouraging experimental studies and proof-of-concept clinical trials, very few of the tested agents/interventions have translated to successful clinical trials and none is on standard clinical use. The failure in translation of cardioprotection to clinical practice has been attributed to many factors, from inadequate animal models to poor clinical study designs. In addition, patients usually have cardiovascular risk factors, co-morbidities and concomitant medications that cannot be overlooked since they may interact with the cardioprotective response. Besides improving the design of the experimental and clinical studies the search for new cardioprotective agents must continue. The use of emerging “omic” technologies and bioinformatics tools holds great promise to identify novel targets of therapeutic relevance and new treatment approaches able to limit the damage of myocardial infarction and attenuate the consequent adverse left ventricular remodeling process.
9 February 2018, 13:00 (Friday, 4th week, Hilary 2018)
Sherrington Building, off Parks Road OX1 3PT
Large Lecture Theatre
Dr Gemma Vilahur (Cardiovascular Research Center (ICCC), IIB-SantPau, Autonomous University of Barcelona (UAB), CiberCV Instituto de Salud Carlos III, Barcelona)
Department of Physiology, Anatomy and Genetics (DPAG)
Sally Collins (University of Oxford)
Organiser contact email address:
Professor Carolyn Carr (DPAG, University of Oxford)
DPAG Head of Department Seminar Series
Members of the University only