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Decoding adaptive immunity in tissues
In-person only
Adaptive immune responses unfold within complex tissue microenvironments that shape clonal selection, effector fate, and long-term immune resilience. I will discuss new spatial transcriptomic technologies we’ve developed which capture the state, receptor sequence, and location of lymphocytes directly in situ. These approaches reveal how T and B cell diversity is organized across germinal centers, inflamed tissues, and aging thymus. By integrating clonal and spatial information, we can map how immune interactions and tissue cues drive adaptation, regeneration, and decline, offering a framework for decoding adaptive immunity across health, aging, and disease.
Date:
8 December 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Dr Sophia Liu (Ragon Institute of MGH, MIT, and Harvard)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Tess Lawless (Kennedy Institute of Rheumatology)
Host:
Professor Calliope Dendrou (University of Oxford)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Theresa Lawless
