The Dr Stanley Ho Memorial Lecture: 'Revisiting genetic determinism: evidence from large population cohorts'
Developments in whole genome sequencing technologies have catalysed incredible progress in the diagnosis of rare disease and the discovery of novel disease-associated genes.

However, large-scale sequencing of population cohorts has revealed that many healthy individuals carry the same disease-causing variants as patients. The extent of this incomplete penetrance in individuals not ascertained on the basis of a family history or clinical diagnosis is neither well understood nor widely appreciated.

In this talk, Professor Caroline Wright, Professor of Genomic Medicine at the Department of Clinical and Biomedical Sciences at the University of Exeter, will outline recent research into penetrance of different diseases across different populations, and discuss the broader implications of these findings for genomic screening.

The talk will be followed by a drinks reception, all welcome.

This is the Dr Stanley Ho Memorial Lecture organised by the Oxford Martin School and the Centre for Personalised Medicine.
Date: 29 April 2024, 17:15 (Monday, 2nd week, Trinity 2024)
Venue: Oxford Martin School, 34 Broad Street OX1 3BD
Venue Details: Lecture Theatre
Speaker: Professor Caroline Wright (University of Exeter)
Organising department: Oxford Martin School
Organisers: Centre for Personalised Medicine, Oxford Martin School (University of Oxford)
Organiser contact email address:
Part of: Oxford Martin School Events
Booking required?: Required
Booking url:
Cost: Free
Audience: Public
Editors: Clara Bowyer, Hannah Mitchell