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Policing secretion: protein quality control and traffic COPs
Research in the Miller lab is broadly aimed at understanding basic mechanisms of secretory protein biogenesis, focusing on protein quality control within the endoplasmic reticulum. They use the budding yeast, Saccharomyces cerevisiae, as a model system, which affords facile biochemical, genetic, genomic and proteomic tools. By using such a tractable model system, they can rapidly discover new pathways and dissect mechanisms that may be directly relevant to a number of human diseases, most notably cystic fibrosis and similar diseases of protein misfolding. Vesicle formation from the ER is relatively well understood and relies on cytoplasmic coat proteins known as the COPII coat. Yet, despite a relatively deep understanding of the mechanisms that drive COPII vesicle formation and cargo capture, we know very little about how this process is regulated to prevent improper traffic of misfolded proteins. One long-term goal is to understand how vesicle abundance and architecture can adapt to changing physiological needs with respect to cargo load.
Date:
14 April 2016, 11:00
Venue:
NDM Building, Headington OX3 7FZ
Venue Details:
TDI, Basement Seminar Room
Speaker:
Dr Liz Miller (MRC Laboratory of Molecular Biology, University of Cambridge)
Organising department:
Ludwig Institute for Cancer Research, Oxford Branch
Organisers:
Mary Muers (Oxford Ludwig Institute, NDM Experimental Medicine),
Alexandra Ward (University of Oxford, Oxford Ludwig Institute, NDM Experimental Medicine)
Organiser contact email address:
alexandra.ward@ludwig.ox.ac.uk
Host:
Dr. John Christianson (Ludwig Cancer Research, Oxford)
Part of:
Ludwig Institute Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Mary Muers
