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Characterising lung mucosal and systemic immune response in humans following inhalation of attenuated Mycobacterium bovis BCG using single cell sequencing.
In person only
Inhaled bacille Calmette–Guérin (BCG) provides a controlled human model to interrogate anti-mycobacterial immunity at defined time points, something not feasible in natural Mycobacterium tuberculosis infection. It also represents a promising mucosal vaccination route that outperforms intradermal (ID) BCG in animal models. We will present updated findings from two clinical trials in healthy adults: BCG-naïve and historically BCG-vaccinated participants received aerosolised BCG, with control groups of BCG-naïve participants given inhaled saline and previously vaccinated participants given ID BCG. Lung mucosal and peripheral blood responses were characterised longitudinally using single-cell RNA sequencing (scRNA-seq) and bulk T-cell receptor (TCR) sequencing.
Date:
5 December 2025, 9:15
Venue:
MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details:
WIMM Seminar room
Speaker:
Shuailin Li (McShane Group, University of Oxford)
Organising department:
MRC Human Immunology Unit
Organisers:
Alina Bovtenko (MRC Translational Immune Discovery Unit, University of Oxford),
Renata Sojka (MRC Translational Immune Discovery Unit, University of Oxford)
Organiser contact email address:
tidu.admin@imm.ox.ac.uk
Part of:
MRC TIDU Friday Morning Lab Meetings
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Renata Sojka,
Alina Bovtenko
