IFN I and IL-10 drive T-cell exhaustion during experimental liver fibrosis
Persistence of viral infection in murine models of liver fibrosis is associated with a severely impaired antiviral T-cell response. Experiments using transgenic mice and specific blockade of cytokine receptors revealed that IFN I and IL-10 are the main drivers of T-cell exhaustion during chronic liver disease.
Date:
7 June 2017, 16:00 (Wednesday, 7th week, Trinity 2017)
Venue:
Medawar Building, off South Parks Road OX1 3SY
Venue Details:
Level 30 seminar room
Speaker:
Carl-Philipp Hackstein (University of Bonn)
Organiser:
Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Host:
Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Lynn Dustin
