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Environment control of T cell function
The T lymphocyte response to pathogens is shaped by the T cell microenvironment and key environmental signals are provided by amino acids, glucose and oxygen. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1 and signaling pathways regulated by intracellular protein O-GlcNAcylation. Other environmental sensors are transcription factors such as c-myc and hypoxia-inducible factor-1 alpha.The present talk will explore the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.
Date:
21 October 2019, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Professor Doreen Cantrell (Professor of Cell Biology and Immunology and Wellcome Trust Principal Research Fellow, University of Dundee)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Jennifer Pope (Kennedy Institute of Rheumatology)
Organiser contact email address:
jennifer.pope@kennedy.ox.ac.uk
Host:
Dr Tal Arnon (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Public
Editor:
Jennifer Pope
