Rank concordance of polygenic indices: Implications for personalized screening
The performance of polygenic indices is typically assessed in terms of the amount of phenotypic variance they explain in independent prediction samples. For some applications, however, the correct ranking of individuals in the polygenic index distribution is of higher importance. Using simulations and empirical applications, we analyze common approaches of polygenic index construction methods in terms of their concordance in ranking individuals. We find that, even for highly heritable traits, (i) the exact ranking of individuals in the polygenic index distribution is characterized by large uncertainty, and (ii) the ranking is highly unstable across construction methods. The profound consequences for personalized screening are illustrated in simulations and with an empirical application for cardiovascular disease in the UK Biobank.
Date: 29 November 2021, 17:30 (Monday, 8th week, Michaelmas 2021)
Venue: This talk will take place on Zoom
Speaker: Dr Fleur Meddens (University of Oxford)
Organising department: Wellcome Trust Centre for Human Genetics
Organisers: Catherine Lidbetter (Centre for Personalised Medicine), Thea Perry (Centre for Personalised Medicine)
Organiser contact email address: cpm@well.ox.ac.uk
Hosts: Catherine Lidbetter (Centre for Personalised Medicine), Thea Perry (Centre for Personalised Medicine)
Part of: Centre for Personalised Medicine Seminars
Booking required?: Required
Booking url: https://us02web.zoom.us/webinar/register/WN_kYUSMYegSRCI-5NNaQQ8eQ
Cost: Free
Audience: Public
Editor: Thea Perry