OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
MHC class I-peptide complexes are usually stable for hours or even days. We have found that small molecules – for example certain dipeptides – that bind into the F pocket can dramatically accelerate peptide dissociation and replacement with exogenous peptides. This works on recombinant class I molecules, where the technology can be used to rapidly manufacture MHC multimers for T cell staining, and on cell surfaces, from which peptides can now be natively eluted.
