Use of network theory to define optimal HIV immune targets: Implications for immunologic control and immunogen design
Viral diversity remains a major challenge to HIV vaccine development. By applying concepts rooted in network theory to viral protein structure, we have developed an algorithm that identifies amino acid residues critical to the structure and function of HIV proteins. Functional data from persons who control HIV without medication demonstrate preferential CD8+ T cell recognition of highly networked residues predicted by the algorithm. Application of this knowledge to inform a rational T cell-based vaccine for HIV will be discussed.
Date:
15 September 2017, 14:00
Venue:
Medawar Building, off South Parks Road OX1 3SY
Venue Details:
Please note the Medawar Building has no reception. If you wish to attend the seminar you will need to call 281231 on arrival for entry.
Speaker:
Professor Bruce Walker (Ragon Institute of MGH, MIT and Harvard)
Organising department:
Nuffield Department of Clinical Medicine
Organiser:
Prof. Philip Goulder (University of Oxford)
Part of:
Peter Medawar Building Seminars
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Rebecca Allen
