Closed-loop Deep Brain Stimulation for the Treatment of Involuntary Movements
The human brain consists of numerous networks distributed over space and connected over time to orchestrate meaningful interaction with the external world. Neurological disorders interrupt this interaction, and in some cases, they lead to involuntary tremors and tic disorders. My research focuses on identifying neural signatures of these disorders in the basal ganglia-thalamocortical networks and electromyographic activity in patients with essential tremor and Tourette Syndrome who are undergoing deep brain stimulation (DBS) therapy. Bidirectional neurostimulators allow for biomarker identification for symptoms, and responsive stimulation overcomes many downsides of continuous DBS therapy to regain control of movement. We have shown the feasibility and safety of bidirectional therapy, i.e., closed-loop stimulation.
Date:
11 June 2025, 10:00
Venue:
Pharmacology, off Mansfield Road OX1 3QT
Venue Details:
Pharmacology Lecture Theatre
Speaker:
Prof. Aysegul Gunduz (University of Florida)
Organising department:
MRC Brain Network Dynamics Unit
Host:
Prof. Timothy Denison (University of Oxford)
Part of:
Brain Network Dynamics Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Nima Mirkhani
