Role of iNKT cells and MAIT cells in HIV-1 infection
Status: This talk is in preparation - details may change
The majority of T lymphocytes recognize antigenic peptide fragments presented by MHC
molecules, and this confers antigen specificity to the adaptive immune system. However, a
significant part of T lymphocytes in fact recognize different types of antigenic structures. A
fairly recently discovered T cell subset is the Mucosa-associated Invariant T (MAIT) cells, which
constitutes up to 10% of circulating T cells in human peripheral blood. MAIT cells were
recently shown to recognize microbial vitamin metabolite antigens presented by the highly
conserved MHC class-like molecule MR1. Another type of non-classical T cells is the invariant
Natural Killer T (iNKT) cells that recognize CD1d-presented glycolipids. Despite that MAIT cells
and iNKT cells recognize very different antigenic structures they have their innate-like response
characteristics in common. In our studies we aim to understand the roles that these innate-like
T cell subsets play in infectious diseases.
Date: 6 November 2015, 16:00 (Friday, 4th week, Michaelmas 2015)
Venue: Medawar Building, off South Parks Road OX1 3SY
Venue Details: Level 30 conference room
Speakers: Speaker to be announced
Topics:
Booking required?: Not required
Audience: Members of the University only
Editor: Lynn Dustin