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Molecular Organisation of Cell Junctions in Epithelial Tissue
In person only
Understanding how does functional order emerges from individual components is a major challenge of current biology. It’s particularly fascinating how epithelial cells organize its components in space and time to shape adhesion mesoscale structures such that they keep a robust and functional architecture that enables tissue homeostasis and organ function. We initially revealed that the initiation of tight junctions is triggered by biomolecular condensates of the protein ZO-1 at the cell adhesion sites. Later, we discovered that a biophysical wetting phenomenon orchestrates the assembly of the tight junction around the apical interface sealing the tissue. We now aim to investigage the molecular assembly of cell-cell adhesions in epithelia tissue and in the pathology of intestinal diseases such IBD exploring biophysical mechanisms involving membrane-condensates. Combining cell biology, super-resolution STED microscopy and chemical biology, we aim to uncover how cells control different physico-chemical environments to drive self-organisation processes that shape mesoscale structures enabling tissue function.
Date:
24 June 2024, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Dr Karina Pombo-Garcia (Rosalind Franklin Institute)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
doris.chan@kennedy.ox.ac.uk
Host:
Dr Adrien Hallou (University of Oxford)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Doris Chan
